it is all up with

(informal)it is the end or there is no hope for (someone or something)

(非正式)对…，一切都完了

on the up and up informal 非正式

(Brit.)steadily improving or becoming more successful

(英)稳步提高

(chiefly N. Amer.)honest or sincere

(主北美)诚实的，正直的

something is up

(informal)something unusual or undesirable is happening or afoot

(非正式)不寻常（或不好）的事发生了

up against it

(informal)facing some serious but unspecified difficulty

(非正式)面对某种困难，面临某种困境

they play better when they're up against it.

面对困难时，他们打得更好。

up and about

no longer in bed (after sleep or an illness)

（睡眠或生病后） 起床；下床

up and doing

active; busy

忙碌的，积极肯干的

a normal young chap wants to be up and doing.

正常的年轻人总想积极向上。

up and down

moving upwards and downwards

一上一下，起伏

bouncing up and down.

上下跳动。

to and fro

来来回回，往返地

pacing up and down in front of her desk.

在她书桌前踱来踱去。

in various places throughout

到处，处处

in clubs up and down the country.

在全国各地俱乐部。

(informal)in varying states or moods; changeable

(非正式)（情绪，状态）多变的

my relationship with her was up and down.

我和她的关系变化不定。

up and running

(especially of a computer system) in operation; functioning

（尤指计算机系统）运行中

the new computer is up and running.

新电脑在运行。

up the ante

the new computer is up and running.

新电脑在运行。

up before

appearing for a hearing in the presence of

出庭面对

we'll have to come up before a magistrate.

我们将不得不出庭面对治安法官。

up for

available for

正待

the house next door is up for sale.

隔壁房子正待出售。

being considered for

被考虑

he had been up for promotion.

他被考虑提升。

due for

到期

his contract is up for renewal in June.

他的合同将在六月到期续签。

up for it

(informal)ready to take part in (a particular activity)

(非正式)准备参加

Nigel was really &B{up for it}, as always.

像平常一样，奈吉尔真准备好参加了。

up hill and down dale

all over the place

到处

he led me up hill and down dale till my feet were dropping off.

他领着我到处走，直到我的腿都快断了。

up top

(Brit. informal)in the brain (with reference to intelligence)

(英，非正式)头脑里（指智力）

a man with nothing much up top.

大脑空空的人。